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Psilocybin & Its Effects on Cognition or Emotional Function

Psilocybin & Its Effects on Cognition or Emotional Function

A recent study sheds some light on the safety profile of psilocybin, the key element in “magic mushrooms.”

The study, published in the Journal of Psychopharmacology, investigates the effects of psilocybin on healthy subjects’ cognitive and affective functioning. While psilocybin is well-known for its potential to alleviate depression over time, its impact on cognitive performance has received much less attention.

COMP360, a trademarked form of psilocybin created by Compass Pathways, was used in the study. The business recently completed the biggest phase 2 psilocybin experiment to date with very encouraging findings. It is now moving on to phase 3.

The study, performed at King’s College London in 2019, found that psilocybin had no negative impacts on cognitive functioning or emotional processing in the short or long term.

The Particulars

The researchers compared the effects of two doses of COMP360 psilocybin to a placebo in 89 healthy male and female adult participants. Respondents were given either a 10mg, a 25mg, or a placebo dose.

The medication was given to up to six volunteers simultaneously. They were also given one-on-one psychological assistance from experienced therapists throughout the six-hour session. A 12-week follow-up period was also included in the study.

The Final Outcome

There were no significant adverse reactions, and COMP360 psilocybin was well without any clinically substantial adverse effects on cognitive performance.

“This rigorous study is an important first demonstration that the simultaneous administration of psilocybin is worth exploring further,” stated the study’s principal author, Dr. James Rucker. “If we think about how psilocybin therapy (if approved) may be delivered in the future, it’s important to demonstrate the feasibility and the safety of giving it to more than one person simultaneously, so we can think about how we scale the treatment up.”

Psilocybin Antidepressant Effects A Year Later

Psilocybin Antidepressant Effects A Year Later

Experts continue to discover even more astounding results demonstrating the efficacy of two doses.

Although numerous studies have shown that psilocybin-assisted therapy effectively relieves depression, it is still a big question about how long the relief lasts.

In 2020, Johns Hopkins University released a study focusing on 24 people with depression who were given 2 sessions of psilocybin-assisted therapy. After 4 weeks, 71% of their patients saw their depression symptoms improve by 50 percent. To add to that, 54 percent were considered in remission.

This meant that their symptoms were not severe enough to warrant a diagnosis of Major Depressive Disorder.

Everyone was highly ecstatic because this proved to be up to 4 times more effective than current anti-depression treatments. However, for psilocybin therapy to be considered a viable treatment option, the effects must hold effective for an extended period. After all, expecting someone to undergo two psilocybin treatments per month would be unreasonable, not to mention impractically expensive.

Continuing the previous study, Johns Hopkins has published the results of a one-year follow-up, and the results are pretty promising. The population of individuals who benefited from the experience increased a full year after receiving the two doses of psilocybin!

An astonishing 78% of participants saw a 50% or more significant reduction in depressive symptoms, while 58% were in remission.

As per Rolland Griffiths, the study’s lead investigator, “Compared to standard antidepressants, which must be taken for long periods, psilocybin has the potential to enduringly relieve the symptoms of depression with one or two treatments.”

The question now is whether the benefit is limited to a single year. Could they possibly last for a more extended period of time? Perhaps even a lifetime?

We are excited to see many more studies done specifically on this topic!

Can Magic Mushrooms Unlock Depression?

Can Magic Mushrooms Unlock Depression?

The sciences are slowly beginning to back the idea that magic mushrooms can help people heal their minds and unwind the damaging effects of depression. It’s not a cure-all, but it does enable the person to feel empowered and capable of taking the proactive steps required to change their circumstances.

This TED Talk from 2017 is from a clinical psychologist from Imperial College describes how Magic Mushrooms (Psilocybin), when used in a therapeutic setting, have been found to be a very effective treatment for depression. In this talk, she draws on her experiences working as a therapist on the groundbreaking Psilocybin for Depression study and introduces us to some of the patients and their stories of transformation.

Dr. Rosalind Watts completed her clinical psychology training at University College London. After six years of practicing psychotherapy in the NHS, she joined a clinical trial at Imperial College, investigating psilocybin (magic mushrooms) as a treatment for depression. Her research explores patients’ positive views of this intriguing therapy.

MD Microdosing Guide

MD Microdosing Guide

Have you thought about Micro-dosing, but are unsure of where to start?

Thousands upon thousands of people are already microdosing with psilocybin and sharing their experiences of working with this sacred plant teacher. Microdosing is not recreational. It is partnering with a valuable medicine that allows you to feel exactly what you need to feel in order to heal from within.

You too can learn from this medicine. This guide will tell you what you need to know to get started on your journey.

A new trend has emerged in the past decades to not only consume hallucinogenic mushrooms for psychedelic trips, but to take minute amounts of it for soul connection, and physiological and self-healing from within.

Because there are numerous kinds of blends available, it may take time to find the dosage that is right for you and your system. Be patient and go slow.

This guide will help you find the mushroom teacher that is right for you, and how to microdose safely.

Microdosing vs Macro-dosing

Microdosing vs Macro-dosing

Often times, the conversation surrounding Psychedelics includes the association of a hallucination experience. As this may be true, it’s not always the case. Indigenous cultures have been working with Psychedelic plants for many thousands of years for not only physical healing but also spiritual worship. Normally they will work with large quantities of Psychedelic plants in a ceremonial setting. This is what we like to refer to as MACRO-dosing.

There is great benefit to occasional Macro-dosing, depending on the user’s end goal. That might be spiritual enlightenment, higher consciousness, or elevated perception. There are a few names for this type of dosing – Macro, Ceremonial, or Hero Dose.

At John Hopkins University, they have been conducting studies for the last few decades on patients who suffer from depression, end of life anxiety, addiction and PTSD with the use of a Hero dose. This is normally 3-5 grams of Psilocybin (Psychedelic) Mushrooms, administered by and monitored by a professional clinician as the patient occasionions their psychedelic experience.

But for those who choose to work with a MICRO-dose, they may only use .1 – .25 grams of Psilocybin, never actually feeling any affects at all. The purpose is not to necessarily feel anything, but to aid in the re-wiring of their neural network in hopes of achieving much of the same desired affects that Macro-dosing offers.

Both are highly beneficial, but to each it’s own. Which path would you prefer to take?

Can Psychedelics Heal PTSD/Trauma?

Can Psychedelics Heal PTSD/Trauma?

Every member of the Mushroom Doctor team is a Veteran whose mission it is to see those who suffer from PTSD find healing and freedom from the the debilitating affects. But we also know that PTSD is not reserved for Veterans alone. In fact, nearly everyone suffers from some form of trauma or another.

If you’ve ever read the book, “The Body Keeps The Score”, you would discover that the author’s assertions from years of study is that trauma is saved like a record in the unconscious mind that we refer to as the body. Trauma can be absorbed at the molecular level and healing can not be found from Talk Therapy alone.

Statistics reveal to us that an average of 22 Veterans commit suicide each day due to PTSD, and many of those were prescribed psychotropic medication with little to no affect. In recent years, many Veterans who suffer from the deteriorating affects of PTSD are finding healing in the arms of Psychedelic Assisted Therapy.

Studies are revealing a rapid decline in PTSD in subjects that work with psychedelic plant medicine on occasional macro-dose or daily micro-dose levels. The exciting news is that they are finding this modality is not only saving lives, but has zero side effects that one might find in prescribed medication.

You don’t have to be a veteran to understand the debilitating nature of PTSD, and you don’t have to continue living with the mental or emotional affliction it brings to your relationships, work, or overall well-being. There is a solution and it’s found in nature. 

“Let Nature Be Your Doctor”