Psychedelics and Neuroscience

Psychedelics and Neuroscience


Psychedelic drugs have a complex and intriguing history when it comes to neuroscience. These substances were used in ancient cultures for spiritual purposes, but in modern times, they became associated with the counterculture movement of the 1960s and recreational use. In recent years, however, the potential therapeutic benefits of these drugs have gained attention, leading to a resurgence of research in the field of psychedelic neuroscience.

Psychedelic drugs are known to produce a range of effects, including sensory distortions, changes in time perception, and altered emotional states. These substances include LSD, psilocybin (the active ingredient in “magic mushrooms”), and MDMA (commonly known as ecstasy).

Understanding Psychedelic Drugs

Psychedelic drugs work by altering the activity of neurotransmitters in the brain, particularly serotonin. Serotonin plays a key role in regulating mood, appetite, and other functions, and psychedelic drugs interact with the serotonin receptors in the brain, affecting how they communicate with other brain cells. By doing so, these drugs can produce changes in perception, mood, and thought patterns.

One of the most well-known effects of psychedelic drugs is the altered state of consciousness they can produce. This can include sensory distortions, such as seeing colors more vividly or hearing sounds more acutely, as well as changes in time perception. Many people report feeling a sense of unity or interconnectedness with the world around them while under the influence of these substances.

Psychedelic Neuroscience Research

In recent years, research in the field of psychedelic neuroscience has been growing rapidly, driven in part by the potential therapeutic applications of these substances. Studies have suggested that psychedelic drugs may have applications in the treatment of a range of mental health conditions, including depression, anxiety, and post-traumatic stress disorder (PTSD).

For example, a study conducted by researchers at Imperial College London found that psilocybin, the active ingredient in magic mushrooms, was effective in reducing symptoms of depression in people who had not responded to other treatments. Similarly, a study conducted by the Multidisciplinary Association for Psychedelic Studies (MAPS) found that MDMA-assisted psychotherapy was effective in reducing symptoms of PTSD in veterans.

Researchers believe that the therapeutic effects of these substances may be due to the way they affect the brain’s neural networks, promoting greater connectivity between different regions of the brain. By doing so, they may be able to help people break out of negative thought patterns and develop new perspectives on their experiences.

Resources and Conclusion

If you’re interested in learning more about psychedelic neuroscience, there are many resources available online. Academic journals like the Journal of Psychedelic Studies and the Journal of Psychoactive Drugs publish the latest research findings in this field. Organizations like MAPS and the Beckley Foundation are also great resources for learning more about the therapeutic potential of psychedelic drugs.

In conclusion, while there is still much we don’t know about the therapeutic potential of psychedelic drugs, research in the field of psychedelic neuroscience is growing rapidly. Studies have suggested that these substances may have applications in the treatment of a range of mental health conditions, and researchers are continuing to explore their potential uses. As research continues, we may gain a better understanding of how these substances work and how they can be used to help people with mental health conditions.


  1. Carhart-Harris, R. L., & Goodwin, G. M. (2017). The therapeutic potential of psychedelic drugs: past, present, and future. Neuropsychopharmacology, 42(11), 2105-2113.
  2. Nichols, D. E., & Johnson, M. W. (2019). Psychedelics as medicines: an emerging new paradigm. Clinical pharmacology and therapeutics, 105(4), 733-735.
  3. Sessa, B. (2018). Can psychedelic compounds play a part in drug dependence therapy? British Journal of Psychiatry, 212(4), 203-205.
  4. Nichols, D. E. (2016). Psychedelics. Pharmacological reviews, 68(2), 264-355.
  5. Multidisciplinary Association for Psychedelic Studies. (2022). About MAPS. Retrieved from https://maps.org/about
  6. Beckley Foundation. (2022). About us. Retrieved from https://www.beckleyfoundation.org/about-us/
What is a “Hero’s Dose” with Mushrooms?

What is a “Hero’s Dose” with Mushrooms?

Magic mushrooms, also known as psilocybin mushrooms, have been used for centuries in various cultures for their medicinal and spiritual properties. In recent years, research has shown that these mushrooms can have profound therapeutic effects when used in a controlled setting. One concept that has emerged from this research is the “hero’s dose,” a term coined by mycologist Paul Stamets.

So, what exactly is a hero’s dose?

Put simply, it’s a large, high-dose amount of psilocybin mushrooms that are taken in a therapeutic or ceremonial setting. The idea behind the hero’s dose is that it can produce a transformative experience that can help individuals overcome mental health challenges and bring about profound personal growth.

The term “hero’s dose” (much different than a microdose)comes from the idea that taking a large dose of psilocybin mushrooms can be akin to embarking on a hero’s journey. Just as a hero must confront and overcome challenges on their quest, individuals taking a hero’s dose may face difficult emotions, memories, and experiences during their trip. However, by confronting and working through these challenges, individuals may emerge from their trip with a newfound sense of clarity, purpose, and resilience.

It’s worth noting that a hero’s dose is not for everyone. It’s a powerful experience that should only be undertaken with careful consideration and under the guidance of a trained professional. In fact, many researchers believe that the therapeutic benefits of psilocybin mushrooms come not just from the substance itself but from the therapeutic setting in which it’s taken.

What Sutdies are Saying:

Studies have shown that psilocybin can be effective in treating a range of mental health conditions, including depression, anxiety, and PTSD. It’s believed that the substance works by disrupting negative thought patterns and allowing individuals to approach their emotions and experiences in a new, more positive way.

While a hero’s dose can be a powerful tool for personal growth and healing, it’s important to remember that it’s not a panacea. Individuals should still seek out traditional forms of therapy and support to supplement their experience with psilocybin mushrooms. It’s also important to ensure that the mushrooms are taken in a safe and controlled setting, with proper guidance and support.

In conclusion:

The hero’s dose is a concept that’s emerged from the therapeutic use of psilocybin mushrooms. While it’s not for everyone, it can be a powerful tool for personal growth and healing when used in a safe and controlled setting. As research continues to uncover the potential benefits of psilocybin mushrooms, it’s important to approach their use with caution and respect, always keeping the potential risks and benefits in mind.



Summertime is some of the best times to explore the wonders of nature! And what better way to do it than hiking on magic mushrooms?! These funky fungi can totally blow your mind and help you see the world in a whole new way. If you’re up for an adventure, here are five essential tips for hiking on mushrooms that’ll make your trip extra groovy:

1 – Pack like a pro

Before you head out into the wilderness, make sure you’ve packed all the essentials you need for a day hike. You don’t want to get caught in the rain without a jacket or be starving because you forgot snacks. So, pack smart and pack right!

2 – Tell someone where you’re going

Whether you’re hiking alone or with a group, it’s crucial to let someone know where you’re going and when you expect to be back. If you’re with a group, you should assign a designated “trip sitter” who stays sober to keep everyone safe. If you’re solo, tell a trusted friend or family member where you’re going and stay in touch with them throughout the day.

3 – Set your intentions

Take some time to think about what you want to get out of your mushroom trip. Do you want a spiritual experience? A social one? Or just a chance to frolic in nature? Make a plan for your hiking adventure, but don’t forget to stay flexible and open to new experiences.

4 – Bring some creature comforts

You’re going to be out in the wild for a while, so why not make it as comfy as possible? Bring along your favorite snacks, music, and anything else that’ll make your trip more enjoyable. And don’t forget a cozy hammock or blanket to relax in when you need a break.

5 – Stay on the trail

Nature is full of wonders, but it’s easy to get lost if you wander too far off the trail. Plus, staying on the path helps protect the environment. So, if you see something cool off the beaten path, take a quick detour but don’t get too far off track.

Extra tip – Have a blast! John Muir, a famous outdoorsman, said, “Climb the mountains and get their good tidings. Nature’s peace will flow into you as sunshine into trees.” So, have fun exploring the great outdoors and let nature work its magic on you! Remember, always be safe and responsible when hiking on mushrooms.

Psilocybin for PTSD

Psilocybin for PTSD

Welcome to the Topic “Psilocybin for PTSD”

As more and more people become aware of their mental health and the possibility of trying out psychological treatment, there comes a time when there are too many people who are struggling. Depending on the illness or condition, mental health care requires professional psychological and medical treatment. While some may be able to make do with psychological therapy, others require medical attention to aid in managing their symptoms and helping them live better lives. 

Unfortunately, sometimes even the tried and tested medicines don’t work. Every person has a differently wired brain, so it may not come as a surprise that every person reacts differently to medications – some may only experience the side effects without receiving any relief from their mental turmoil. 

Most times, in these cases, the professional may recommend psychological therapy. Both psychological and medical treatment are meant to work in tandem with each other, with joint reliance on both of them to maximize healing and recovery. However, in some cases with severe mental disorders, medication may be necessary for the individual to be able to deal with their psychological problems effectively. One such condition is PTSD. 

What is PTSD?

Psilocybin for PTSD

PTSD is somewhat of a buzzword these days, but few are aware of its severity and prevalence. PTSD is short for Post Traumatic Stress Disorder, which is an intensely alternated mental state wrought with anxiety, paranoia, and depression following a traumatic event. In fact, their mental state is so heavily changed that they may find it challenging, if not impossible, to perform daily functions. 

For such a condition, it becomes essential to use psychological treatments and medications in conjunction. This is because besides the psychological effects, the patient may be dealing with, they also may experience a lack of sleep, loss of appetite, intense anxiety, and other symptoms that must be managed before they can entirely focus on their mental recovery. The problem is that there are only so many practical, tried, and tested medications on the market. Besides antidepressants and antibiotics, patients may engage in psychotherapy. However, sometimes, even the combinations of these two treatments do not produce the results desperately needed. 

As the need for medication rises, medical professionals have begun experimenting with alternative types of medication. Specifically, recent research focuses on magic mushrooms’ potential as a treatment. 

How can psychedelic mushrooms be used for treatment?

Magic mushrooms or psychedelic mushrooms are increasingly being used in research to observe the effects of the drug on individuals. These mushrooms carry an ingredient known as psilocybin – this psychedelic compound stimulates your neural connections and brain cells. Because the drug is mainly taken for abuse or recreation, the amount taken usually results in vivid hallucinations and a changed state of mind. 

However, that does not mean that the material itself is harmful – as with any drug, the user is responsible for the effects. There is no doubt that psilocybin has the potential to stimulate neurogenesis. An individual suffering from PTSD may greatly benefit from such material. 

Psilocybin is a substance that mainly targets the hippocampus. This part of the brain is responsible for emotions and memory, both of which are the primary functions impacted by PTSD. Patients with PTSD may find it extremely difficult to control their emotions and regulate them in a  way that benefits their emotional, mental, and physical health. In addition, because PTSD is a result of an incredibly traumatic event, the affected individual usually loses their recollection of the events. This is because the memory of the event is so harmful and upsetting that the brain decides that the individual is better off and healthier by keeping that painful experience repressed. 

That said, an individual must learn to recover from that trauma, and for that, they need control over their emotions and memories. Because psilocybin can potentially repair neural connections, increase communication and improve the growth of new brain cells, the brain can learn new ways to process events, adapt to new circumstances, and heal from the painful past. 

Psilocybin for PTSD

How does psilocybin impact the brain?

Psilocybin also stimulates the neurotransmitter of serotonin. This particular chemical is essentially a mood booster. Varying levels of serotonin can greatly impact one’s mood and, consequently, the quality of their life. Individuals who have PTSD almost always experience depression as a comorbid condition. The stress and anxiety of the trauma, along with the hopelessness of depression, can completely alter one’s life, and one of the reasons is the imbalance of serotonin. Because of the mood-boosting properties of psilocybin, it is possible to incorporate it into the treatment of such patients and help improve their mood. A better mood improves how your day goes, and consecutive good days make it easier for your mind to destress and focus on the good things in life. 

With all that said, it is essential to keep in mind that psychedelic mushrooms and other drugs are still widely illegal throughout the world. This is mainly due to the chances of the drugs being abused for recreation and leisure and further harming the users. Furthermore, there is always a possibility that medical professionals and scientists do not abide by ethics and administer distorted amounts of the drug to further their research. 

In addition to those complaints, it must be noted that the population in question is extremely vulnerable to any significant changes, physical and mental. Unfortunately, there is not enough proof for the usefulness of psilocybin in treating PTSD. These people have already suffered too much trauma in their lives to be subjected to an entirely new harmful experience due to intake of the drug. As of now, it is simply too inhumane to administer this drug freely – the risk is too high. Considering the hallucinogenic properties, it is more probable that the substance ends up hurting the affected individuals more than helping them. 

The possibility of this substance being incorporated into psychological treatment is low, but that does not mean it doesn’t exist. More research needs to be conducted regarding the use of psilocybin in psychological treatments for PTSD.

Have any questions regarding the topic “Psilocybin for PTSD,” feel free to comment below.

Also Read: Psilocybin: Can It Help Lessen Weight Gain?

Benefits of ayahuasca

Benefits of ayahuasca

Words like “life-changing,” “transformative,” “healing,” and “enlightening” are frequently used while discussing ayahuasca. The definitions of these phrases, however, are somewhat ambiguous. So what impact does ayahuasca have on people? The responses differ from person to person. It’s hard to know what will occur for any one individual throughout their ayahuasca encounter. Due to its volatile nature as a hallucinogenic, there is no confirmation about what a user may experience. 

It allows for the healing of the body, mind, and spirit.

Although an increasing amount of research is being conducted on the topic of ayahuasca and its potential benefits for mental and spiritual health, this is one of the reasons why indigenous people have long since incorporated ayahuasca into their customers. Countless people have reported incredible ayahuasca healing after ingesting the ayahuasca tea. Physical, mental, emotional, and spiritual healing all fall under various categories, but they are frequently related in some manner. Ayahuasca has been used successfully by people to treat a wide range of physical conditions, including chronic and fatal illnesses like cancer and tumors. Even more effective than standard treatments for mental and emotional problems is ayahuasca. Ayahuasca is frequently helpful in helping people heal from the difficulties and prevailing negativity still existing after experiencing trauma. These may include events such as physical, emotional, or sexual abuse, the loss of a loved one, or any other type of trauma that most people have encountered in their lives.

It may help in treating mild anxiety and depression.

Depression and anxiety are two of the most prevalent disorders that ayahuasca is particularly good at curing. After just two or three ayahuasca ceremonies, it’s fairly unusual for people to experience a lifting of their sadness (and a permanent cure).

Ayahuasca aids in our recovery from the melancholy and hopelessness that permeate so many aspects of our life by re-establishing our connection to the spiritual realm and our true selves. Numerous scientific research conducted throughout the years has demonstrated the potent antidepressant properties of ayahuasca.

Benefits of ayahuasca
Benefits of ayahuasca

It allows for complete purification of the self. 

Most participants in several Ayahuasca rituals will undergo a significant amount of purging. While you may vomit and perhaps spit a lot during an ayahuasca purge, you’re not merely ejecting physical matter. Coughing, shaking, weeping, laughing, and sweating is the material type of purging. In contrast, ayahuasca has an effect on one’s mental state as well. The ayahuasca purge helps you eliminate all the negative energies and emotions built up during your lifetime, often without your knowledge. This may be one of the most intense emotional experiences for some people, which frequently helps with various mental health difficulties. Both these purges are needed for deep cleaning of the self – in other words, you are left with a clean slate. 

It helps you on your self-discovery journey.  

People frequently go to ayahuasca retreats to discover their purpose or a new path in life. People frequently start to feel entirely dissatisfied with their existing professions and vocations as they begin the awakening process. However, they still often feel unsure about what they really want to accomplish with their life. Most spiritually conscious people believe that having a purpose and meaning in life is crucial. Following an ayahuasca trip, people frequently make some quite drastic adjustments to their life. Because they suddenly have a crystal clear understanding of what they must do to add more joy and significance to their lives, many people who have always hated their vocations or jobs eventually decide to leave them.

It helps combat the consequences of healing from addiction. 

There are many different types of addiction. In today’s day and age, many people suffer from addiction and substance abuse disorders. Purging from addiction is not as easy as other people assume, mainly because there are too few ways to aid rehabilitation. This is why the affected individuals frequently seek out ayahuasca to heal from addiction. After taking ayahuasca, it’s not unusual for people to overcome all types of addictions. Ayahuasca has been shown to be a highly successful treatment for drug and alcohol addiction. Specific facilities, like Taki Wasi, are dedicated to assisting clients in overcoming their addictions via ayahuasca and other Amazonian plant remedies. I know from personal experience that an ayahuasca retreat or ceremony causes profound alterations in the neurological system.

Benefits of ayahuasca
Benefits of ayahuasca

It allows you to know yourself better. 

Nothing helps you know yourself better than figuring out the most profound, subconscious, or unconscious desires. This knowledge may not be accessible to you regularly, but it is possible to further your journey of self-discovery through ayahuasca. Ayahuasca is excellent for assisting you in delving deeper into the recesses of your own mind and frequently reveals many aspects of yourself that you might not have been consciously aware of. Psychedelics tap into the deepest parts of your mind, so there is nothing more authentic than what you experience through their intake. What you find through this trip may surprise you – people are often not what they think themselves to be. 

It increases creativity.

Creativity is something that exists beyond the conscious perception and awareness of an individual. After taking ayahuasca, many creative people (or even those who didn’t previously consider themselves creative) have discovered that their creativity has improved. To fully tap into your creative reserves, an otherworldly experience is necessary. Artists paint better, authors write better, and musicians often compose better music. Ayahuasca will probably be helpful if you feel you have a creative spark inside of you that needs to be ignited.

Ayahuasca may indeed have seemingly miraculous benefits for some individuals. Still, it’s crucial to emphasize that this plant medicine is by no means a magical cure-all – it is important not to treat it as such. Ayahuasca doesn’t work for everyone, and not everyone receives what they seek.

Limiting your demands and expectations to an absolute minimum is crucial if you want to use ayahuasca. High expectations can result in people not finding what they seek, leading to further disappointment. 

Have any questions regarding the topic “Benefits of ayahuasca,” feel free to comment below.

Also Read: Ayahuasca for depression